Oriel.org Medical Research Resources

Saturday August 19, 2017
Uremia & Uremia research

Uremia is termed as a disease that is described by a kidney failure. In a kidney failure (or in other words, a renal failure) waste products, such as urea and other nitrogenous substances, are retained in the ill person's blood while in normal conditions the kidney functions include the excretion of the waste products into the urine. Uremia can result from any disorder that impairs the functioning of the kidneys or that hinders the excretion of urine from the body.



The illness of uremia is viewed as one of the most serious that can lead to the fatal outcome. The symptoms of uremia are different. They can be early and late, light and serious. Among the very first signs are complete tiredness, weariness, and a loss of mental concentration. The ill person can feel a continuous itching sensation that is usually accompanied by muscle twitching or other unintentional movings. The patient's skin gets flaky, dry, and becomes of a particular color from yellowish to tan. The mouth has a dry metallic taste, and from the breath you can distinct a certain odour that is like ammonia. Loss of appetite can develop into vomiting and nausea, and there are common occurrence of diarrhea and constipation. Moreover, among the early symptoms the researches mark out anorexia and lethargy, while the late symptoms include decreased mental acuity and coma. In the more serious stages of the disease, the accumulation of nitrogenous waste products in the blood and the whole body leads a different derangement of the nervous, cardiovascular, and respiratory systems and can result in high pressure, convulsions, heart attack, and death.

As the matter of the fact, there are a lot of dysfunctions that can result from uremia. They may affect many systems of the body, for instance blood (the level of erythropoietin decreases), sex (the level of testosterone or estrogen lowers) and bones (osteoporosis and metastatic calcifications).

As the chief cause of uremia is damage of the kidneys, the modern uremia research include the detection of the reasons that cause the illness (whether the reason is Bright's disease (or glomerulonephritis), hypertension (or high blood pressure), diabetes mellitus, or any other disorder that lowers kidney function). The treatment of uremia lies upon the identification and treatment of the disorder that is the underlying reason of the disease. Patients whose kidneys are ill and who are waiting for kidney transplants often suffer various degrees of uremia. In these cases uremia, along with other syndromes due to renal insufficiency, is best treated by dialysis - that is the artificial filtering of the blood stream by a machine outside the body. The researchers are developing the artificial kidney transplants because when optimal treatment fails transplants become an option vital for further living. The variant of transplant should be carefully considered and evaluated with the professionals in medicine to learn the possible success compared to the serious risks and risks of developmental delay or lymphoproliferative disease as a side effect of immunosuppression or immunosuppressants.

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