The ORIEL Project
...is
developing tools and procedures to promote access to and integration
of a wide range of information resources in the life sciences.
The tools
developed through ORIEL will:
-
enable effective linking of different types of biological
information (literature, factual and multimedia databases)
-
make navigation easy, thereby encouraging the creative
exploration of the information landscape
-
facilitate communication by making data presentation and
information visualisation user-friendly.
- The ORIEL
Project (IST-2001-32688), funded by the EU and coordinated by the
European Molecular Biology Organisation (EMBO) aims to provide
research communities with tools to manage large, complex,
multimedia datasets and to navigate through an increasingly
intricate and potentially confusing information landscape.
Methodologies
- ORIEL's
methodologies will be tested and applied in a critical user
environment represented by the EU-funded E-BioSci platform
(QLRI-CT-2001-30266).
Developments
- Methods -
- leading
to the creation of new concepts of the scientific
literature, based on machine-understandable documents.
-
Technologies -
-
permitting effective linking of a wide range of
biological digital information sources, including molecular,
genomic and multi-dimensional image databases,
-
promoting ease of cross-database navigation, leading to
creative exploration of the information landscape.
- Protocols
-
-
facilitating effective data representation and
information visualisation through the construction of
adaptive interfaces that meet the needs of individual users.
Background
- The emerging
fields of genomics and bio-informatics are having
far-reaching effects on all aspects of the Life Sciences.
Additionally, biotechnology and biomedicine, that will benefit
enormously from new genome-based technologies, have become important
growth areas in the European life sciences industry.
- Genomics
research is characterized by the production of vast amounts of
raw and derived data. The integration of the exponentially
growing amounts of these and associated biological information in
digital form (publications, sequence and sequence-related
information, digital image data) is presenting one of the most
demanding current challenges to information technology.
- There is an
urgent need to better exploit the potential of the Internet
and other communication networks to develop novel technology and
intelligent middleware for the integration of large, complex and
disparate information resources.
Objectives
- The ORIEL
project will explore and further develop methods, technologies
and protocols aimed at the integration, dissemination and
exploitation of large, complex and disparate digital information
resources. With a view to making such technologies widely available,
it will focus on the Life Sciences as a data-intensive and highly
demanding testbed that will
- permit
effective linking of different types of biological
information displaying complex inter-relationships (literature,
factual and multi-media image databases)
-
promote ease of navigation leading to creative exploration
of the information landscape and
-
facilitate user-friendly data presentation and information
visualisation.
Milestones
- The
development of new concepts that will enhance the efficiency of
integration of different types of biological data currently
maintained in a wide spectrum of digital collections and resources
across Europe.
- The
development and optimization of interactive and adaptive user
interfaces to promote intelligent access to, retrieval and
analysis of data stored in digital form.
E-BioSci and ORIEL
- E-BioSci is
EMBO's initiative to provide a federated network of European
platforms for a wide range of high quality electronic services
relating to information access and retrieval in the life sciences.
- The ORIEL
Project will promote access to and integration of E-BioSci
services. In return, E-BioSci will provide a staging area in
which ORIEL components can be pre-released prior to rigourous
testing by sub-sets of research community users. This staging
facility will serve both as development area for testing and
integrating ORIEL prototypes within E-BioSci, as well as evaluating
their effectiveness with core users of the live service.
- Both projects
build on the complementary expertises and strengths of partner
institutions in different locations in Europe. They aim to foster
optimal pooling and use of European biological archives and data
collections, and will involve the development of common
protocols for efficient searching and retrieval of different types
of information (including images, sequence data and full text
published literature) held in different locations and in different
formats. Some of these goals are long term and will require
significant research and prototyping to achieve them.
Graphic representation of the relationships between ORIEL and E-BioSci
projects

ORIEL
Partners
CINES
| CNR-IBC |
CNR-ITB |
CSIC |
EBI |
EMBO |
EUR |

CINES (Centre
Informatique National de l'Enseignement Supérieur)
(Workpackages WP5, WP6, WP7)
- Created in 1980 in
Montpellier (France), CINES is supervised by the French Ministry of Research
and provides the French research community with computing resources and
services. CINES' three core competencies are:
- High performance
computing: Numerous scientific disciplines use equipment of the Centre
for resolving problems which require extreme powers of calculation and large
memory capacities. CINES also offers users the possibility to visualise the
results of calculations by animated sequences and to produce supports of
broadcasting.
- Large databases
and documentation systems: CINES is the privileged partner of the Higher
Education Bibliographical Agency (ABES) as well as the official server of
the libraries network SIBIL-FRANCE. CINES is also involved in several
multimedia projects.
- Wide Area Network
expertise: CINES is connected to the French National Research Network
(RENATER) and also participates in the national network committee CRU and
its different workgroups. A RENATER local office will soon be located in the
CINES building. Many collaborations are in progress between RENATER and
CINES, including security and performance.


CNR-IBC (Consiglio
Nazionale delle Ricerche) (National Research Centre)
(Workpackage WP3, WP6, WP7)
- Hosts the CNR-EMMA
facility of the European Mouse Mutant Archive. In collaboration with
European partners and the Mouse Genome DataBase at the Jackson Laboratory,
it has defined informatics policies aimed at the implementation of the
EMMA-Resource DataBase (EMMA-RDB).
- For more information,
please vist http://www.cnr.it.
CNR-ITB
(Consiglio Nazionale delle Ricerche) (National Research Centre)
(Workpackage WP3, WP6, WP7)
- Bio-informatics
division of CNR, which was established in 1989 to work on the framework of
the Human Genome Project. Originally focused on developing tools for
the genome sequence analysis and prediction of gene structure in different
organisms, attention has more recently been shifted towards study of
genefunction, promoter prediction, gene expression analysis and the
development of databases integrated with sequence analysis tools.
- For more information,
please vist http://www.cnr.it.

CSIC (Consejo
Superior de Investigaciones Científicas)
(Workpackage WP4, WP7)
- The
Spanish Council for
Scientific Research (CSIC), established in 1939, is the largest
multidisciplinary public research organisation in Spain. It is an
autonomous body within the Ministry of Science and Technology and its main
objective is to promote and carry out research contributing to scientific
and technological progress in Spain. The CSIC can be considered as the
backbone for development of science and technology in Spain. The research
activities of CSCI cover virtually every field of knowledge: Agricultural
Sciences, Biology & Biomedicine, Chemistry, Science & Technology, Food
Science & Technology, Humanities & Social Sciences, Materials Science &
Technology, Natural Resources, Physics: Science & Technology
- As a part of its
commitment to the Spanish scientific community, the CSIC makes available a
part of its infrastructure and a variety of services, among which mention
may be made of its information, documentation and library networks.
- For more information,
please visit:
http://www.csic.es


EMBL-EBI (European
Bioinformatics Institute)
(Workpackage WP4, WP7)
- The European
Bioinformatics Institute (EBI) is the central European node for managing
factual databases in the Life Sciences. The following databases are
managed at the EBI:
- The International
DNA data library, the Swissprot and SPTREMBL protein database,
the EMBL Interpro database of protein families, the European
Macromolecular Structure Database (MSD), the Array Express database
of microarray data and the ENSEMBL databases of annotated large scale
genomic sequence.
- In addition to
providing these databases and services built on top of these, EBI has a
vigorous research role in bioinformatics. Both data sources and new
algorithms are investigated and developed at the EBI, along with research
into technical developments to enable new technologies to be deployed for
life sciences.
- EBI is at the Hinxton
Wellcome Trust Genome Campus, which is the world's premier campus for public
domain large scale life science data research.
- For more information,
please visit:
http://www.ebi.ac.uk.

EMBO
(European Molecular Biology Organization)
(Workpackages WP0, WP7, WP8)
-
Active development and support of trans-national approaches to molecular
biology through fellowships, courses and workshops. Leads in European
molecular biology publishing (EMBO Journal, EMBOreports).
- For more information,
please visit:
http://www.embo.org.

BioSemantics Group, Department of Medical Informatics, Erasmus University
The Biosemantics Group
Rotterdam is an initiative of the
Department of Medical
Informatics of the Erasmus MC - University Medical Center Rotterdam, the
Netherlands. Through innovative fundamental and applied research it aims at
developing and validating advanced techniques for the processing and analysis of
large, complex, and heterogeneous medical and biological data sets. In addition
to research the group is involved in the training of under- and postgraduate
medical students and radiologists.

ICGEB
(International Centre for Genetic Engineering and Biotechnology)
(Workpackage WP3, WP7)
- International
research organization focussing on advanced research and teaching in
molecular biology and biotechnology. Maintains the ICGEBnet
Bioinformatics Service with over 1100 users throughout the world.
Bioinformatics research at ICGEB is carried out in two main areas: a)
Maintenance and development of SBASE protein sequence domain library and b)
physico-chemical properties of DNA.
- For further
information, please visit:
http://www.icgeb.trieste.it.

IGH (Institut
de Génétique Humaine)
(Workpackage
WP5, WP6, WP7)

ingenta
(Workpackages
WP1, WP6)
- Ingenta was formed
through a public/private partnership with the University of Bath to provide
electronic distribution and marketing for the publishers of scholarly
content and to develop the industry's primary portal site for the knowledge
worker. Ingenta operates the renowned BIDS services for the UK higher
education community. Ingenta bases its North American operation in
Cambridge, MA and its European operations in Oxford and Bath, UK.
- In March 2000 Ingenta
merged with the UnCover Company and in May 2000 it became listed on the AIM
market of the London Stock Exchange. In June 2000 Ingenta acquired the
Publishers Communication Group (PCG), based in Cambridge, MA. In October
2000, Ingenta acquired Dynamic Diagrams. In February 2001, Ingenta merged
with CatchWord. In March 2002, Ingenta acquired HERON, formerly a
government-funded initiative providing online course packs to Higher
Education Institutions in the UK.
- The combined company
currently works for almost 200 publisher clients, and hosts or links to
5,400+ academic journals. The Group’s customer base includes 7 of the
world’s top 8 journal publishers – Blackwell Publishing, Elsevier Science (including
Academic Press), John Wiley & Sons, Kluwer Academic Publishers, Oxford
University Press, Taylor & Francis and the Sage Group.
- For more information,
please visit:
http://www.ingenta.com

INRIA (Institut
National de Recherche en Informatique et Automatique)
(Workpackage
WP2, WP7)

LIRMM (Laboratoire
d'Informatique, de Robotique et de Microéelectronique de Montpellier)
(Workpackage
WP5, WP6, WP7)
UOXFAT -
University of
Oxford
(Workpackage
WP1, WP7)
- Founding partner of
the 4th Framework
BioImage Database Project, with responsibility for digital video
data. Experience in digital video encoding and compression artefacts,
automated content analysis and query by content of biological videos.
Developer of VIDOS, a patent-pending Web-based video editing and
customization tool.
- For more information,
please visit:
http://www.ox.ac.uk.